Computer Metaphors for Biochemistry

The metaphor of the computer represents in some crude fashion the chemistry of life. Nowadays one may assume that the average citizen of an industrialized country is at least as familiar with computers as with rain forests. The idea of using the computer as a metaphor is a natural one. A computer is a device for handling information according to a program which it is able to remember and execute. A living cell, to remain in control of its vital functions in a variable environment, must also p...

 Science Communication: Definitions VS Metaphors

A hundred years ago, Charles Darwin could write books discussing the central problems of biology in language which was scientifically precise and still accessible to the general public. In those days the subject matter of biology was plants and animals. The language of Darwin was intelligible to experts and non-experts alike. One did not need a degree in {55} botany to understand the difference between a fern and a flower. Darwin could assume that his readers were familiar with the world of...

 Science Unifiers

Now it is generally true that the very greatest scientists in each discipline are unifiers. This is especially true in physics. Newton and Einstein were supreme as unifiers. The great triumphs of physics have been triumphs of unification. We almost take it for granted that the road of progress in physics will be a wider and wider unification bringing more and more phenomena within the scope of a few fundamental principles. Einstein was so confident of the correctness of this road of unificati...

 If a Scientist Wrote the Book of Genesis

In the beginning was the singularity, and the singularity was infinitely dense and infinitely hot, And the singularity expanded and the singularity cooled and there was chaos, And of the primeval atom was born the Universe. And the Universe was matter and antimatter, and baryogenesis was violated and matter annihilated antimatter until only matter remained, And matter resolved into hydrogen, and after hydrogen came helium and deuterium and all elements, And with elements came mass and with ma...

 The Sequence Hypothesis and The Central Dogma

My own thinking (and that of many of my colleagues) is based on two general principles, which I shall call the Sequence Hypothesis and the Central Dogma. The direct evidence for both of them is negligible, but I have found them to be of great help in getting to grips with these very complex problems. I present them here in the hope that others can make similar use of them. Their speculative nature is emphasized by their names. It is an instructive exercise to attempt to build a useful theory ...